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Regenerative medicine
Nature Biotechnology
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Cross-species analysis of thymic stroma in mice and humans reveals a subset of mesenchymal cells that are capable of restoring thymic function, which suggests new strategies for thymus regeneration.
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References
-
Gustafsson, K. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-025-02864-w (2025).
-
Kooshesh, K. A., Foy, B. H., Sykes, D. B., Gustafsson, K. & Scadden, D. T. N. Engl. J. Med. 389, 406–417 (2023).
ArticleÂ
PubMedÂ
PubMed CentralÂGoogle ScholarÂ
-
Yayon, N. et al. Nature 635, 708–718 (2024).
ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂGoogle ScholarÂ
-
Kousa, A. I. et al. Nat. Immunol. 25, 1593–1606 (2024).
ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂGoogle ScholarÂ
-
Nitta, T. & Takayanagi, H. Front. Immunol. 11, 620894 (2021).
ArticleÂ
PubMedÂ
PubMed CentralÂGoogle ScholarÂ
-
Handel, A. E. et al. Sci. Adv. 8, eabm9844 (2022).
ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂGoogle ScholarÂ
-
Cui, G. et al. Proc. Natl Acad. Sci. USA 111, 1915–1920 (2014).
ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂGoogle ScholarÂ
-
Love, P. E. & Bhandoola, A. Nat. Rev. Immunol. 11, 469–477 (2011).
ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂGoogle ScholarÂ
-
Bhalla, P. et al. J. Clin. Invest. 132, e160101 (2022).
ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂGoogle ScholarÂ
-
Savage, T. M. et al. Sci. Adv. 9, eadc9436 (2023).
ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂGoogle ScholarÂ
Download references
Acknowledgements
We thank all members of our laboratories for important discussions, enthusiastic scientific input and continual support. We are grateful to V. Zimmerman and J. Dudakov for their critical insights. The authors were supported by the Intramural Research Program of the National Institutes of Health (NIH). The contributions of the NIH authors were made as part of their official duties as NIH federal employees, are in compliance with agency policy requirements, and are considered Works of the US Government. However, the findings and conclusions presented in this paper are those of the authors and do not necessarily reflect the views of the NIH or the US Department of Health and Human Services.
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Moraly, J., Suh, J. & Taylor, N. Mesenchymal cells rebuild the thymus.
Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02821-7
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DOI: https://doi.org/10.1038/s41587-025-02821-7
